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breast carcinoma amplified sequence 3 (GAOB1, Maab1 protein, BCAS3)

Structure: - contains 3 WD repeats Compartment: nucleus Alternative splicing: named isoforms=5 Expression: - expressed in stomach, liver, lung, kidney, prostate, testis, thyroid, adrenal, brain, heart, skeletal muscle, colon, spleen, small intestine, placenta, blood leucocyte, mammary epithelial cells Pathology: - overexpressed in most breast cancer cell lines - a chromosomal translocation t(17;20)(q23;q13) involving BCAS3 with BCAS4 may be a cause of breast cancer

General

nuclear protein WD repeat protein family

Properties

SIZE: MW = 101 kD entity length = 928 aa COMPARTMENT: cell nucleus MOTIF: WD repeat {69-114} WD repeat {349-389} WD repeat {403-447} Breakpoint for translocation to form BCAS4-BCAS3 {824-825}

Database Correlations

OMIM 607470 UniProt Q9H6U6

References

  1. UniProt :accession Q9H6U6
  2. Atlas of Genetics and Cytogenetics in Oncology and Haematology http://atlasgeneticsoncology.org/Genes/BCAS3ID766.html