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breast cancer metastasis-suppressor 1-like protein (BRMS1-homolog protein p40, BRMS1-like protein p40, BRMS1L)
Function:
- role in the histone deacetylase (HDAC1)-dependent transcriptional repression activity
- when overexpressed in lung cancer cell line that lacks p53/TP53 expression, inhibits cell growth
- component of the Sin3/HDAC1 corepressor complex
- interacts with HDAC & SIN3A
Structure: belongs to the BRMS1 family
Compartment: nucleus (probable)
General
nuclear protein
Properties
SIZE: entity length = 323 aa
MW = 38 kD
COMPARTMENT: cell nucleus
MOTIF: coiled coil {52-84}
coiled coil {149-180}
Database Correlations
UniProt Q5PSV4
Pfam PF08598
References
UniProt :accession Q5PSV4
Component-of
corepressor complex