BRCA2 & CDKN1A-interacting protein (protein TOK-1, BCCIP, TOK1)

Function: - may promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A - may be required for repair of DNA damage by homologous recombination in conjunction with BRCA2 - interacts with BRCA2 & CDKN1A Structure: belongs to the BCP1 family Compartment: - nucleus - colocalizes with BRCA2 in discrete nuclear foci Alternative splicing: named isoforms=3 Expression: - expressed at high levels in testis & skeletal muscle & at lower levels in brain, heart, kidney, liver, lung, ovary, pancreas, placenta, & spleen - isoform 1 is expressed throughout the cell cycle - isoform 2 is expressed following mitosis & peaks in G1/S phase of cell cycle

Related

breast cancer type 2 susceptibility protein (Fanconi anemia group D1 protein, BRCA2, FACD, FANCD1) cyclin-dependent kinase inhibitor 1; p21WAF1/CIP1; p21; CDK-interacting protein 1; melanoma differentiation-associated protein 6; MDA-6 (CDKN1A, CAP20, CDKN1, CIP1, MDA6, PIC1, SDI1, WAF1)

General

nuclear protein phosphoprotein

Properties

SIZE: MW = 36 kD entity length = 314 aa COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S42} BRCA2 interaction {59-167} MOTIF: Ser phosphorylation site {S112} Ser phosphorylation site {S115} CDKN1A interaction {161-259}

References

UniProt :accession Q9P287