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[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial; branched-chain alpha-ketoacid dehydrogenase kinase; BCKD-kinase; BCKDHKIN (BCKDK)
Function:
- catalyzes phosphorylation & inactivation of the branched-chain alpha-ketoacid dehydrogenase complex, the key regulatory enzyme of the valine, leucine & isoleucine catabolic pathways
- dehydrogenase (acetyl-transferring)] phosphate
- autophosphorylated (putative)
ATP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] = ADP + [3-methyl-2-oxobutanoate
Structure:
- monomer (putative)
- belongs to the PDK/BCKDK protein kinase family
- contains 1 histidine kinase domain
Compartment: mitochondrial matrix
Expression: ubiquitous
Related
branched-chain ketoacid dehydrogenase
General
kinase or ATP-phosphotransferase
mitochondrial protein
phosphoprotein
Properties
SIZE: entity length = 412 aa
MW = 46 kD
COMPARTMENT: mitochondrial matrix
MOTIF: Ser phosphorylation site {S31}
Ser phosphorylation site {S33}
Thr phosphorylation site {T35}
Ser phosphorylation site {S52}
Histidine kinase {159-404}
Database Correlations
UniProt O14874
PFAM correlations
Entrez Gene 10295
Kegg hsa:10295
ENZYME 2.7.11.4
References
UniProt :accession O14874