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brain-specific serine protease 4; BSSP-4; serine protease 22; serine protease 26; tryptase epsilon (PRSS22, BSSP4, PRSS26, SP001LA, UNQ302/PRO343)
Function:
- serine protease
Structure:
- belongs to the peptidase S1 family
- contains 1 peptidase S1 domain
Compartment: secreted
Expression:
- expressed abundantly in the epithelial cells of the airways, including trachea, esophagus & fetal lung
- scarce in adult lung
- expressed at low levels in placenta, pancreas, prostate & thyroid gland
Note:
- no mention of expression in the brain
General
glycoprotein
secreted protein
serine protease
Properties
SIZE: entity length = 317 aa
MW = 34 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-32}
S1 domain {50-290}
MOTIF: N-glycosylation site {N70}
cysteine residue {C75}
MODIFICATION: cysteine residue {C91}
histidine residue {H90}
cysteine residue {C91}
MODIFICATION: cysteine residue {C75}
aspartate residue {D141}
cysteine residue {C175}
MODIFICATION: cysteine residue {C248}
cysteine residue {C208}
MODIFICATION: cysteine residue {C227}
cysteine residue {C227}
MODIFICATION: cysteine residue {C208}
cysteine residue {C238}
MODIFICATION: cysteine residue {C266}
serine residue {S242}
cysteine residue {C248}
MODIFICATION: cysteine residue {C175}
cysteine residue {C266}
MODIFICATION: cysteine residue {C238}
Database Correlations
OMIM 609343
UniProt Q9GZN4
Pfam PF00089
Entrez Gene 64063
Kegg hsa:64063
References
- UniProt :accession Q9GZN4