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brain-derived neurotrophic factor; BDNF; abrineurin (BDNF)

Function: - neurotrophic for dopaminergic neurons of substantia nigra, sensory neurons of nodose ganglion, retinal ganglion cells & septal cholinergic cells - along withother neurotrophins, binds to & activates gp145trkB - role in long-term potentiation - during development, promotes survival & differentiation of selected neuronal populations of the PNS & CNS - role in axonal growth, pathfinding & in modulation of dendritic growth & morphology - major regulator of synaptic transmission & plasticity at adult synapses in many regions of the CNS - versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including a) long-term potentiation (LTP) b) long-term depression (LTD) c) certain forms of short-term synaptic plasticity d) homeostatic regulation of intrinsic neuronal excitability - converted into mature BDNF by plasmin (PLG) (putative) - binds to NTRK2/TRKB - implicated in regulation of food intake & body weight in rodents Structure: - the propeptide is N-glycosylated & glycosulfated - monomers & homodimers - belongs to the NGF-beta family Compartment: secreted Alternative splicing: - named isoforms=5 - also alternative promoter usage: - 2 types of transcripts are produced - non-coding transcripts (antisense, opposite strand, 8 exons) - coding transcripts (11 exons) - brain BDNF & anti-BDNF transcripts form dsRNA duplexes Expression: - expressed in brain - highly expressed in hippocampus, amygdala, cerebral cortex & cerebellum - also expressed in heart, lung, skeletal muscle, testis, prostate & placenta Polymorphism: - variations in BDNF are associated with susceptibility to bulimia nervosa 2 - defects in BDNF are a cause of congenital central hypoventilation syndrome (Ondine curse)

Interactions

molecular events

Related

BDNF gene BDNF genotyping BDNF/NT-3 growth factors receptor; EC=2.7.10.1; neurotrophic tyrosine kinase receptor type 2; TrkB tyrosine kinase; GP145-TrkB; Trk-B (NTRK2 TRKB)

General

glycoprotein neurotrophic factor or neurotrophin secreted protein

Properties

SIZE: entity length = 247 aa MW = 28 kD COMPARTMENT: extracellular compartment MOTIF: signal sequence {1-18} proteolytic site {57-58} N-glycosylation site {N121} cysteine residue {C141} MODIFICATION: cysteine residue {C208} cysteine residue {C186} MODIFICATION: cysteine residue {C237} cysteine residue {C196} MODIFICATION: cysteine residue {C239} cysteine residue {C208} MODIFICATION: cysteine residue {C141} cysteine residue {C237} MODIFICATION: cysteine residue {C186} cysteine residue {C239} MODIFICATION: cysteine residue {C196}

Database Correlations

OMIM correlations MORBIDMAP 113505 UniProt P23560 Pfam PF00243 Entrez Gene 627 Kegg hsa:627

References

  1. Hohn A, Leibrock J, Bailey K, Barde YA. Identification and characterization of a novel member of the nerve growth factor/brain-derived neurotrophic factor family. Nature. 1990 Mar 22;344(6264):339-41. PMID: 2314473
  2. Hyman C et al BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra. Nature 350:230 1991 PMID: 2005978
  3. Journal Watch 23(6):48, 2003 Egan MF et al Cell 112:257, 2003
  4. Entrez Gene :accession 627
  5. UniProt :accession P23560
  6. Wikipedia; Note: BDNF entry http://en.wikipedia.org/wiki/brain-derived_neurotrophic_factor