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bradykinin B2 receptor; BK-2 receptor; B2R (BDKRB2 BKR2)
Function:
- receptor for bradykinin
- associated with G proteins that activate phosphatidylinositol-Ca+2 second messenger system
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane
Alternative splicing: named isoforms=2
Expression:
- ubiquitous
- widespread in normal smooth muscle tissue & neurons
Pharmacology:
- icatibant, a specific antagonist of bradykinin B2 receptors, is approved in Europe for treatment of hereditary angioedema
Interactions
molecular events
General
bradykinin receptor
glycoprotein
Properties
SIZE: entity length = 391 aa
MW = 44 kD
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-60}
MOTIF: N-glycosylation site {N30}
N-glycosylation site {N39}
transmembrane domain {61-84}
cytoplasmic loop {85-93}
transmembrane domain {94-118}
exoplasmic loop {119-131}
MOTIF: cysteine residue {C130}
MODIFICATION: cysteine residue {C211}
transmembrane domain {132-153}
cytoplasmic loop {154-175}
transmembrane domain {176-198}
exoplasmic loop {199-221}
MOTIF: N-glycosylation site {N207}
cysteine residue {C211}
MODIFICATION: cysteine residue {C130}
transmembrane domain {222-248}
cytoplasmic loop {249-267}
transmembrane domain {268-292}
exoplasmic loop {293-311}
transmembrane domain {312-335}
cytoplasmic domain {336-391}
MOTIF: cysteine residue {C351}
MODIFICATION: palmitate
COMPARTMENT: membrane
MISC-INFO: LIGAND = KALLIDIN
INHIBITOR = D-ARG0_[HYP3_D-PHE7]BRADYKININ
Database Correlations
OMIM 113503
UniProt P30411
Pfam PF00001
KEGG correlations
References
- UniProt :accession P30411
- Wikipedia; Note: bradykinin receptor entry
http://en.wikipedia.org/wiki/bradykinin_receptor
- SeattleSNPs
http://pga.gs.washington.edu/data/bdkrb2/
- Schini et al
Bradykinin stimulates the production of cyclic GMP via
activation of B2 kinin receptors in cultured porcine aortic
endothelial cells.
J Pharmacol Exp Ther 1990 Feb;252(2):581-5
PMID: 2156053