bradykinin B1 receptor; BK-1 receptor; B1R (BDKRB1, BRADYB1)

Function: - receptor for bradykinin - may play role in chronic pain & inflammation Structure: belongs to the G-protein coupled receptor 1 family Compartment: cell membrane

General

bradykinin receptor glycoprotein

Properties

SIZE: entity length = 353 aa MW = 40 kD COMPARTMENT: cellular membrane MOTIF: exoplasmic domain {1-40} MOTIF: N-glycosylation site {N14} N-glycosylation site {N22} transmembrane domain {41-64} cytoplasmic loop {65-73} transmembrane domain {74-98} exoplasmic loop {99-111} MOTIF: cysteine residue {C110} MODIFICATION: cysteine residue {C189} transmembrane domain {112-133} cytoplasmic loop {134-155} transmembrane domain {156-178} exoplasmic loop {179-199} MOTIF: N-glycosylation site {N185} cysteine residue {C189} MODIFICATION: cysteine residue {C110} transmembrane domain {200-226} cytoplasmic loop {227-247} transmembrane domain {248-272} exoplasmic loop {273-291} transmembrane domain {292-314} cytoplasmic domain {315-353} MOTIF: cysteine residue {C330} MODIFICATION: palmitate COMPARTMENT: membrane MISC-INFO: LIGAND = DES-ARG9_BRADYKININ LIGAND = DES INHIBITOR = LEU8-DES-ARG9_BRADYKININ INHIBITOR = LEU9-DES-ARG10_KALLIDIN

Database Correlations

OMIM 600337 UniProt P46663 Pfam PF00001 Kegg hsa:623