Search
brachyury protein; protein T (T)
Function:
- role in transcriptional regulation of genes required for mesoderm formation & differentiation
- binds to a palindromic site (called T site) & activates gene transcription when bound to such a site
- monomer (putative)
Structure:
- contains 1 T-box DNA-binding domain
Compartment: nucleus
Pathology:
- genetic variations in protein T are associated with susceptibility to neural tube defects
- a protein T gene duplication is involved in susceptibility to the development of chordoma
General
T-box (TBX) protein
Properties
SIZE: entity length = 435 aa
MW = 47 kD
COMPARTMENT: cell nucleus
MOTIF: T-box domain
SITE: 51-219
Database Correlations
OMIM correlations
UniProt O15178
Pfam PF00907
Entrez Gene 6862
Kegg hsa:6862
References
- UniProt :accession O15178
- Entrez Gene :accession 6862