borealin (Dasra-B, hDasra-B, cell division cycle-associated protein 8, pluripotent embryonic stem cell-related gene 3 protein, CDCA8, PESCRG3)

Function: 1) component of the chromosomal passenger complex (CPC) - in the complex, directs CPC to centromeric DNA (putative) 2) cell-cycle regulated, increases during G2/M phase, diminishes after exit from M phase 3) mediates phosphorylation of Ser-10 of histone H3 (putative) Structure: may form homooligomers Compartment: - nucleus, nucleolus, cytoplasm - localizes on chromosome arms & inner centromeres from prophase through metaphase, transfers to spindle midzone & midbody from anaphase through cytokinesis Expression: - cell-cycle regulated - increases during G2/M phase & then reduces after exit from M phase

General

nuclear protein phosphoprotein

Properties

SIZE: entity length = 280 aa MW = 31 kD COMPARTMENT: cytoplasm cell nucleus MOTIF: centromere localization {1-88} MOTIF: Ser phosphorylation site {S15} Ser phosphorylation site {S23} Thr phosphorylation site {T106} Ser phosphorylation site {S110} glutamate-rich region {125-133} MOTIF: glutamate residue (SEVERAL) Ser phosphorylation site {S154} Ser phosphorylation site {S164} Ser phosphorylation site {S165} Thr phosphorylation site {T189} Ser phosphorylation site {S194} Thr phosphorylation site {T204} Ser phosphorylation site {S219} Ser phosphorylation site {S244} Ser phosphorylation site {S274}

Database Correlations

OMIM 609977 UniProt Q53HL2 Pfam PF10512 Entrez Gene 55143 Kegg hsa:55143

References

UniProt :accession Q53HL2