bone sialoprotein 2; bone sialoprotein II; BSP II; cell-binding sialoprotein; integrin-binding sialoprotein (IBSP, BNSP)

Function: - binds tightly to hydroxyapatite - segments of clustered carboxyl groups may mediate the strong binding to hydroxyapatite - appears to form an integral part of the mineralized matrix - probably important to cell-matrix interaction - promotes Arg-Gly-Asp-dependent cell attachment Structure: - N-glycosylated - glycans consist of sialylated & core-fucosylated bi-, tri- & tetra-antennary chains - O-glycosylated at eight sites - mucin-type glycans contain gal, GlcNAc, galNAc & terminal neuAc - sulfated on either Tyr-313 or Tyr-314 Compartment: secreted

General

cell adhesion protein phosphoprotein sialoglycoprotein

Properties

SIZE: entity length = 317 aa MW = 35 kD COMPARTMENT: extracellular compartment MOTIF: signal sequence {1-16} Ser phosphorylation site {S31} acidic region {65-173} MOTIF: acidic residue (SEVERAL) Ser phosphorylation site {S67} Ser phosphorylation site {S74} Ser phosphorylation site {S75} glutamate-rich region {76-83} MOTIF: glutamate residue (SEVERAL) Ser phosphorylation site {S94} Ser phosphorylation site {S100} N-glycosylation site {N104} Thr glycosylation site {T119} Thr glycosylation site {T122} Ser phosphorylation site {S149} glutamate-rich region {151-158} MOTIF: glutamate residue (SEVERAL) N-glycosylation site {N177} N-glycosylation site {N182} N-glycosylation site {N190} Thr glycosylation site {T227} Thr glycosylation site {T228} Thr glycosylation site {T229} Thr glycosylation site {T238} Thr glycosylation site {T239} Ser phosphorylation site {S280} Cell attachment site {286-288}

Database Correlations

OMIM 147563 UniProt P21815 Pfam PF05432 Entrez Gene 3381 Kegg hsa:3381

References

UniProt :accession P21815