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Bombesin receptor-3; BRS-3 (BRS3)
Function:
- role in sperm cell division, maturation, or function
- mediates action via G proteins that activate a phosphatidylinositol-Ca+2 second messenger system
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane
Expression:
- expressed in germ cells of testis
Pathology:
- expressed in lung carcinoma cells
General
bombesin receptor
glycoprotein
Properties
SIZE: entity length = 399 aa
MW = 44 kD
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-41}
MOTIF: N-glycosylation site {N10}
N-glycosylation site {N18}
transmembrane domain {42-63}
cytoplasmic loop {64-82}
transmembrane domain {83-103}
exoplasmic loop {104-121}
MOTIF: cysteine residue {C120}
MODIFICATION: cysteine residue {C203}
transmembrane domain {122-143}
cytoplasmic loop {144-163}
transmembrane domain {164-184}
exoplasmic loop {185-220}
MOTIF: cysteine residue {C203}
MODIFICATION: cysteine residue {C120}
transmembrane domain {221-241}
cytoplasmic loop {242-272}
transmembrane domain {273-293}
exoplasmic loop {294-313}
transmembrane domain {314-333}
cytoplasmic domain {334-399}
MOTIF: cysteine residue {C347}
MODIFICATION: palmitate
COMPARTMENT: membrane
Database Correlations
OMIM 300107
UniProt P32247
Pfam PF00001
Kegg hsa:680
References
UniProt :accession P32247