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BMP-2-inducible protein kinase; BIKe; (BMP2K, BIKE, HRIHFB2017)
Function:
- serine/threonine protein kinase
- may be involved in osteoblast differentiation
- autophosphorylated (putative)
Structure:
- belongs to the protein kinase superfamily, Ser/Thr protein kinase family
- contains 1 protein kinase domain
Compartment: nucleus
Alternative splicing: named isoforms=3
General
nuclear protein
serine/threonine kinase
Properties
SIZE: entity length = 1161 aa
MW = 129 kD
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S10}
glycine-rich region {12-40}
MOTIF: Ser phosphorylation site {S14}
kinase domain
SITE: 51-316
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 57-65
ATP-binding site
NAME: ATP-binding site
SITE: 79-79
aspartate residue {D180}
Ser phosphorylation site {S378}
histidine-rich region {425-559}
MOTIF: histidine residue (SEVERAL)
Ser phosphorylation site {S665}
Ser phosphorylation site {S680}
Ser phosphorylation site {S685}
Ser phosphorylation site {S728}
Ser phosphorylation site {S824}
Ser phosphorylation site {S826}
Thr phosphorylation site {T942}
Ser phosphorylation site {S947}
Ser phosphorylation site {S979}
Thr phosphorylation site {T1002}
Thr phosphorylation site {T1011}
Ser phosphorylation site {S1029}
Ser phosphorylation site {S1031}
Ser phosphorylation site {S1032}
Ser phosphorylation site {S1041}
Ser phosphorylation site {S1076}
Ser phosphorylation site {S1107}
Ser phosphorylation site {S1111}
STATE: active state
Database Correlations
UniProt Q9NSY1
Pfam PF00069
Entrez Gene 55589
Kegg hsa:55589
ENZYME 2.7.11.1
References
UniProt :accession Q9NSY1