BMP & activin membrane-bound inhibitor homolog (transmembrane protein NMA, non-metastatic gene A protein, BAMBI, NMA)

Function: - negatively regulates TGF-beta signaling Compartment: membrane Expression: - expressed in renal medulla, placenta, spleen > renal cortex, liver, prostate, gut - Not expressed in normal skin - expression is high in melanocytes Pathology: - diminished or no expression in metastatic melanoma

General

glycoprotein membrane protein

Properties

SIZE: MW = 29 kD entity length = 260 aa COMPARTMENT: cellular membrane MOTIF: signal sequence {1-20} N-glycosylation site {N87} transmembrane domain {153-173}

Database Correlations

OMIM 604444 UniProt Q13145 Pfam PF06211

References

UniProt :accession Q13145