BMP/retinoic acid-inducible neural-specific protein 3; DBCCR1-like protein 1 (BRINP3, DBCCR1L, DBCCR1L1, FAM5C)

Function: - inhibits neuronal cell proliferation by negative regulation of the cell cycle transition - promotes pituitary gonadotrope cell proliferation, migration & invasion, when overexpressed Structure: - belongs to the BRINP family - contains 1 MACPF domain Compartment: - secreted (putative) - mitochondria Expression: - strongly expressed in oral keratinocytes - weak expression in tongue squamous cell carcinoma - expressed in endothelial & aortic smooth muscle cells - overexpressed in gonadotropinomas Pathology: - may play a role in cell pituitary tumor development

General

glycoprotein secreted protein

Properties

SIZE: entity length = 766 aa MW = 88 kD COMPARTMENT: mitochondria MOTIF: signal sequence {1-33} MACPF {74-264} MOTIF: N-glycosylation site {N168} N-glycosylation site {N337} N-glycosylation site {N456} N-glycosylation site {N562} N-glycosylation site {N609} N-glycosylation site {N641}

Database Correlations

UniProt Q76B58 Pfam PF01823 Entrez Gene 339479 Kegg hsa:339479

References

UniProt :accession Q76B58