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BMP/retinoic acid-inducible neural-specific protein 1; deleted in bladder cancer protein 1 (BRINP1, DBC1, DBCCR1, FAM5A, IB3089A)
Function:
- inhibits cell proliferation by negative regulation of the G1/S transition
- mediates cell death
- not classical apoptosis
- regulates expression of components of the plasminogen pathway
Structure:
- belongs to the BRINP family
- contains 1 MACPF domain
Compartment: cytoplasm
Alternative splicing: named isoforms=3
Expression:
- expressed in brain > heart, lung, skeletal muscle, kidney, thymus, prostate, testis, small intestine
Pathology:
- gene deleted in bladder cancer (transitional cell carcinoma)
- silenced by methylation in 50% of bladder cancer cell lines
General
glycoprotein
Properties
SIZE: entity length = 761 aa
MW = 89 kD
COMPARTMENT: cytoplasm
MOTIF: signal sequence {1-19}
MACPF {68-251}
MOTIF: N-glycosylation site {N156}
N-glycosylation site {N433}
N-glycosylation site {N443}
N-glycosylation site {N553}
N-glycosylation site {N599}
N-glycosylation site {N631}
N-glycosylation site {N677}
Database Correlations
OMIM 602865
UniProt O60477
Pfam PF01823
Entrez Gene 1620
Kegg hsa:1620
References
UniProt :accession O60477