polycomb complex protein BMI-1; polycomb group RING finger protein 4; RING finger protein 51 (BMI1, PCGF4, RNF51)

Function: - component of polycomb group (PcG) multiprotein PRC1 complex - component of E3 ubiquitin ligase complex or polycomb repressive complex 1-like at least composed of PHC2, BMI1, RING1 & RNF2 - part of a complex consisting of BMI1, CUL3 & SPOP - interacts with SPOP - interacts with E4F1 Structure: contains 1 RING-type Zn⁺² finger Compartment: nucleus. cytoplasm Pathology: - cooperates with the MYC oncogene to produce B-cell lymphomas

General

DNA-binding protein phosphoprotein proto oncogene protein ring finger protein

Properties

SIZE: entity length = 326 aa MW = 37 kD COMPARTMENT: cytoplasm cell nucleus MOTIF: RING-finger {18-57} EFFECTOR-BOUND: Zn+2 FOR-BINDING-OF: DNA motif nuclear translocation signal {81-95} E4F1 interaction {164-228} serine-rich region {251-326} MOTIF: serine residue (SEVERAL) Ser phosphorylation site {S251} Ser phosphorylation site {S253} Ser phosphorylation site {S255}

Database Correlations

OMIM 164831 UniProt P35226 Pfam PF00097 Entrez Gene 648 Kegg hsa:648

References

UniProt :accession P35226