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Blimp-1 protein; B lymphocyte-induced maturation protein; PR-domain zinc finger protein 1; beta-interferon gene positive-regulatory domain I binding factor; positive regulatory domain I-binding factor 1; PRDI-binding factor-1 (BLIMP1, PRDM1, PRD1-BF)
Function:
- elevated expression of blimp-1 protein in mature B cells results in J chain transcription, expression of syndecan-1 & onset of IgM secretion
Expression:
- expressed in activated B cells & plasma cells
Related
Blimp-1 gene
General
C2H2 type zinc finger protein
transcription factor, not classified
Properties
SIZE: entity length = 856 aa
MW = 96 kD
COMPARTMENT: cell nucleus
MOTIF: acidic region {71-87}
MOTIF: acidic residue (SEVERAL)
PEST region
SITE: 351-394
proline-rich region
SITE: 360-400
MOTIF: proline residue (SEVERAL)
proline-rich region
SITE: 422-439
MOTIF: proline residue (SEVERAL)
Zn finger C2H2-type
SITE: 608-628
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 636-656
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 664-684
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 692-712
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 720-740
EFFECTOR-BOUND: Zn+2
acidic region {752-800}
MOTIF: acidic residue (SEVERAL)
Database Correlations
OMIM 603423
UniProt O75626
PFAM correlations
References
- Huang S.
Blimp-1 is the murine homolog of the human transcriptional
repressor PRDI-BF1.
Cell. 1994 Jul 15;78(1):9. No abstract available.
PMID: 8033216
- UniProt :accession O75626