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bleeding time

Normal range: 1) Ivy: 2-7 minutes (7-11 minutes is borderline) 2) Simplate* (template): 2.5-9.5 minutes 3) Mielke (template): < 10 minutes 4) Mielke (modified): 2.8 +/- 1.6 minutes 5) Duke (ear lobe): 1-3 minutes * (method of choice) Increases: (prolonged bleeding time) 1) thrombocytopenia (platelets < 60,000-80,000/uL) 2) Glanzmann's thrombasthenia 3) von Willebrand's disease 4) Bernard-Soulier syndrome 5) disseminated intravascular coagulation (DIC) 6) storage pool disease 7) Wiskott-Aldrich syndrome 8) Chediak-Higashi syndrome 9) oculocutaneous albinims 10) hereditary hemorrhagic telangiectasias 11) Ehlers-Danlos syndrome 12) myeloproliferative disorders 13) multiple myeloma & Waldenstrom's macroglobulinemia 14) vasculitis 15) uremia 16) drugs a) anti-platelet agents b) non-steroidal anti-inflammatory agents c) heparin may be associated with increased bleeding time d) tricyclic antidepressants e) high-dose beta-lactam antibiotics f) phenothiazines g) methylxanthines Notes: - not reliable [4] - rarely indicated [4] - largely replace by platelet aggregation measurement [4]

Related

Bernard-Soulier disease (giant platelet syndrome, benign Mediterranean macrothrombocytopenia) disseminated intravascular coagulation (DIC) Glanzmann's thrombasthenia risk for hemorrhage; hemorrhagic diathesis; bleeding disorder storage pool disease thrombocytopenia uremia von-Willebrand's disease (vWD)

Specific

bleeding time Duke bleeding time Ivy

General

clinical hematology test

References

  1. Mayo Internal Medicine Board Review, 1998-99, Prakash UBS (ed) Lippincott-Raven, Philadelphia, 1998, pg 437-38
  2. Clinical Guide to Laboratory Tests, 3rd edition, NW Tietz ed, WB Saunders, Philadelphia, 1995 - Henry's Clinical Diagnosis & Management by Laboratory Methods, 21st edition, McPherson RA & Pincus MR (es), W.B. Saunders Co., Philadelphia, PA. 2007
  3. Interpretation of Diagnostic tests, 8th edition, Wallach J, Lippincott, Williams & Wilkens, Philadelphia, 2007, pg 520
  4. Medical Knowledge Self Assessment Program (MKSAP) 16, American College of Physicians, Philadelphia 2012

Component-of

coagulation screening panel