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biotin deficiency
Etiology:
- excessive consumption of raw eggs than contain avidin a protein that binds biotin & renders it unavailable
- pregnancy disposes
Epidemiology:
- rare
Pathology:
- impaired immune system
Clinical manifestations:
- alopecia, fine & brittle hair
- conjunctivitis
- dermatitis
- seborrheic dermatitis
- scaly, erythematous
- around eyes, nose, mouth, genitals
- neurologic manifestations
- lethary, depression
- hallucinations
- myalgias
- numbness & paresthesias of extremities
- sensorineural hearing loss
- GI manifestations
- nausea, vomiting
- anorexia
- unusual facial fat distribution
Management:
- biotin supplementation
Related
biotin (vitamin B7, vitamin H)
General
vitamin B deficiency
References
- Scheinfeld NS and Freilich SB
Biotin Deficiency
http://emedicine.medscape.com/article/984803-overview
- Wikipedia: Biotin
http://en.wikipedia.org/wiki/Biotin