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biotin (vitamin B7, vitamin H)
Function:
- coenzyme in the metabolism of fatty acids & leucine
- role in gluconeogenesis
- role in the citric acid cycle
- functions in the transfer carbon dioxide
- cofactor in several carboxylases:
a) acetyl-CoA carboxylase
b) 3-methylcrotonyl-CoA carboxylase
c) propionyl-CoA carboxylase
d) pyruvate carboxylase
Epidemiology:
- biotin is present in food protein bound or as biocytin
Pathology:
- avidin in egg whites binds to biotin rendering it unavailable
- avidin is denatured by heat
- biotin deficiency is rare
Dosage:
- recommended daily allowance is 3 ug/day
- up to 300 mg/day has been prescribed for multiple sclerosis [2]
Test interactions:
- high intake make result in falsely low serum troponin [2]
- interference with thyroid function tests with biotin > 5-10 mg/day
- high free T4, low serum TSH [3]
Related
biotin deficiency
General
B vitamin
cofactor
heterocyclic compound, 2 rings
sulfur compound
Properties
Database Correlations
PUBCHEM correlations
Kegg map/map00780
References
- Wikipedia: Biotin
http://en.wikipedia.org/wiki/Biotin
- FDA MedWatch Nov 28, 2017
Biotin (Vitamin B7): Safety Communication - May Interfere
with Lab Tests.
https://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm586641.htm
- FDA Safety Communcation. Nov 5, 2019
- UPDATE: The FDA Warns that Biotin May Interfere with Lab Tests:
https://www.fda.gov/medical-devices/safety-communications/update-fda-warns-biotin-may-interfere-lab-tests-fda-safety-communication
- Biotin Interference with Troponin Lab Tests - Assays Subject
to Biotin Interference.
https://www.fda.gov/medical-devices/vitro-diagnostics/biotin-interference-troponin-lab-tests-assays-subject-biotin-interference
- Medical Knowledge Self Assessment Program (MKSAP) 19
American College of Physicians, Philadelphia 2022
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alpha tocopherol/ascorbate/biotin/biotin/cobalamin/ergocalciferol/folic acid/multivitamin/nicotinamide/panthenol/pyridoxine/riboflavin/thiamine/vitamin a/vitamin k
alpha tocopherol/ascorbate/biotin/cholecalciferol/cobalamin/folic acid/nicotinamide/panthenol/pyridoxine/riboflavin/thiamine/vitamin a/vitamin k
alpha tocopheryl acetate/ascorbate/biotin/carbonyl iron/cobalamin/copper sulfate/folic acid/sodium docusate
alpha tocopheryl acetate/ascorbate/biotin/carbonyl iron/cobalamin/folic acid/sodium docusate
ascorbate/biotin/calcium carbonate/cobalamin/dextran/folic acid/iron dextran/nicotinic acid/pantothenate/pyridoxine/riboflavin/thiamine
ascorbate/biotin/calcium carbonate/cobalamin/ferrous fumarate/folic acid/magnesium oxide/nicotinamide/pantothenate/pyridoxine/riboflavin/thiamine/vitamin a/vitamin e/zinc oxide
ascorbate/biotin/calcium carbonate/cobalamin/ferrous fumarate/folic acid/magnesium oxide/nicotinamide/pantothenate/pyridoxine/riboflavin/thiamine/vitamin a/vitamin e/zinc/zinc oxide
ascorbate/biotin/cholecalciferol/cobalamin/folic acid/nicotinic acid/pantothenate/pyridoxine/riboflavin/thiamine
ascorbate/biotin/cobalamin/copper sulfate/ferrous fumarate/folic acid/magnesium sulfate/manganese sulfate/nicotinic acid/pantothenate/polysaccharide iron complex/pyridoxine/riboflavin/thiamine/zinc sulfate
ascorbate/biotin/cobalamin/folic acid/nicotinamide/pantothenate/pyridoxine/riboflavin/thiamine
ascorbate/biotin/cobalamin/folic acid/nicotinic acid/pantothenate/pyridoxine/riboflavin/thiamine
ascorbate/biotin/ferrous fumarate/folic acid/iron/methylcobalamin/nicotinamide/pantothenate/pyridoxine/riboflavin/thiamine
ascorbate/biotin/folic acid/methylcobalamin/nicotinamide/pantothenate/pyridoxine/riboflavin/thiamine
ascorbate/biotin/folic acid/methylcobalamin/nicotinamide/pantothenate/pyridoxine/riboflavin/thiamine/zinc citrate
biotin/chromium/chromium picolinate
biotin/cysteine/silicon
biotin/cysteine/silicon dioxide
biotin/minoxidil
biotin/nad/panthenol/zinc pyrithione
biotin/nicotinamide/panthenol/zinc pyrithione
biotin/panthenol
biotin/zinc pyrithione