Search
bionic pancreas
Investigational, wearable, automated, bihormonal device
Also see automated closed-loop insulin delivery
Indications:
- diabetes mellitus type 1
Procedure:
- continuous glucose monitor
- delivers glucagon & insulin, based on an adaptive algorithm
Clinical significance:
- better glycemic control than insulin pump
- lowers mean plasma glucose & duration of hypoglycemia [2]
Notes:
- iLet bionic pancreas, an automated system that requires patients to input only body weight & broadly estimated carbohydrate content of upcoming meals (usual, more or less)
Related
automated closed-loop insulin delivery; automated insulin dosing controller; automated glycemic controller device; artificial pancreas
General
prosthesis
pancreas
References
- Russell SJ et al
Outpatient Glycemic Control with a Bionic Pancreas in Type 1
Diabetes.
N Engl J Med. June 15, 2014
PMID: 24931572
http://www.nejm.org/doi/full/10.1056/NEJMoa1314474
- El-Khatib FH et al.
Home use of a bihormonal bionic pancreas versus insulin pump
therapy in adults with type 1 diabetes: A multicentre
randomised crossover trial.
Lancet 2016 Dec 19;
PMID: 28007348
- Murphy HR, Stewart ZA.
Automated insulin delivery: What's new, needed, and next?
Lancet 2016 Dec 19;
PMID: 28007347
- Bionic Pancreas Research Group.
Multicenter, randomized trial of a bionic pancreas in type 1 diabetes.
N Engl J Med 2022 Sep 29; 387:1161.
PMID: 36170500
https://www.nejm.org/doi/10.1056/NEJMoa2205225
- Sherr J.
Seeking simpler solutions with diabetes technology.
N Engl J Med 2022 Sep 29; 387:1228.
PMID: 36170505
https://www.nejm.org/doi/10.1056/NEJMe2210686