biogenesis of lysosome-related organelles complex-1 (BLOC-1 complex)

Function: - biogenesis of specialized organelles of the endosomal- lysosomal system, including melanosomes & platelet-dense granules Structure: - consists of: - BLOC1S1, BLOC1S2, BLOC1S3, DTNBP1, MUTED, PLDN CNO/cappuccino, SNAPAP

Properties

SUBUNITS: biogenesis of lysosome-related organelles complex-1 subunit 1 MOTIF: Thr phosphorylation site {T107} biogenesis of lysosome-related organelles complex-1 subunit 2 MOTIF: coiled coil {79-127} biogenesis of lysosome-related organelles complex-1 subunit 3 MOTIF: Ser phosphorylation site {S30} Ser phosphorylation site {S32} Ser phosphorylation site {S33} Ser phosphorylation site {S34} Thr phosphorylation site {T63} Ser phosphorylation site {S65} dysbindin MOTIF: coiled coil {88-181} Dysbindin {173-331} MOTIF: Ser phosphorylation site {S316} Ser phosphorylation site {S321} protein cappuccino homolog MOTIF: coiled coil {136-165} Muted protein homolog MOTIF: coiled coil {154-186} Palladin MOTIF: immunoglobulin superfamily domain {271-360} MOTIF: cysteine residue {C292} MODIFICATION: cysteine residue {C344} cysteine residue {C344} MODIFICATION: cysteine residue {C292} Ser phosphorylation site {S401} immunoglobulin superfamily domain {440-539} MOTIF: cysteine residue {C462} MODIFICATION: cysteine residue {C521} cysteine residue {C521} MODIFICATION: cysteine residue {C462} VASP interaction {562-566} proline-rich region SITE: 563-567 MOTIF: proline residue (SEVERAL) membrane region proline-rich region SITE: 634-864 MOTIF: proline residue (SEVERAL) LASP1 interaction {646-676} ARGBP2/SPIN90/SRC interaction {676-696} EPS8 interaction {766-831} ARGBP2/SPIN90/SRC/PFN1 interaction {796-831} VASP interaction {819-823} ACTN interaction {833-890} MOTIF: Thr phosphorylation site {T877} Ser phosphorylation site {S893} Ser phosphorylation site {S979} Ser phosphorylation site {S984} immunoglobulin superfamily domain {1001-1085} Ser phosphorylation site {S1116} Ser phosphorylation site {S1118} Ser phosphorylation site {S1121} immunoglobulin superfamily domain {1135-1226} MOTIF: VIL2 interaction {1137-1226} cysteine residue {C1156} MODIFICATION: cysteine residue {C1208} cysteine residue {C1208} MODIFICATION: cysteine residue {C1156} immunoglobulin superfamily domain {1233-1324} VIL2 interaction {1236-1326} Ser phosphorylation site {S1333} SNARE-associated protein Snapin MOTIF: coiled coil {37-126} MOTIF: Ser phosphorylation site {S50} FOR-PHOSPHORYLATION-BY: protein kinase A

References

Swiss-Prot {P78537, Q6QNY0, O95295}

Components

biogenesis of lysosome-related organelles complex-1 subunit 1 (BLOC-1 subunit 1, GCN5-like protein 1, RT14 protein, BLOC1S1, BLOS1, GCN5L1, RT14) biogenesis of lysosome-related organelles complex-1 subunit 2 (BLOC-1 subunit 2, centrosome-associated protein, BLOC1S2, BLOS2) biogenesis of lysosome-related organelles complex-1 subunit 3 (BLOC-1 subunit 3, BLOC1S3, BLOS3) dysbindin; dysbindin-1; dystrobrevin-binding protein 1; Hermansky-Pudlak syndrome 7 protein; HPS7 protein; my031 protein (DTNBP1) Muted protein homolog (MUTED, BLOC1S5) Palladin (sarcoma antigen NY-SAR-77, SIH002, PALLD, KIAA0992, CGI-151) protein cappuccino homolog (CNO, BLOC1S4) SNARE-associated protein Snapin; synaptosomal-associated protein 25-binding protein; SNAP-associated protein (SNAPAP, SNAP25BP, SNAPIN)