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bioengineering
Indications:
- bioengioneering can produce bioidentical blood vessels for shunts & other purposes [1]
- creation of a biodegradable mesh cylinder, seeded with human vascular cells, placed in a bioreactor where culture media could be pulsed through it constantly
- and extracellular matrix with strong mechanical properties gradually forms, replacing the biodegradable cylinder
- the human vascular cells that had created the matrix are destroyed (immunologically incompatible with recipient)
- resulting acellular cylinders were placed in patients for various purposes (dialysis. shunts)
General
procedure
References
- Kirkton RD, Santiago-Maysonet M, Lawson JH et al.
Bioengineered human acellular vessels recellularize and evolve
into living blood vessels after human implantation.
Sci Transl Med 2019 Mar 27; 11:eaau6934
PMID: 30918113
https://stm.sciencemag.org/content/11/485/eaau6934