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biliverdin reductase cycle

Cycle regenerating bilirubin oxidized by ROS* .----> biliverdin ---. | | | |--- NADPH | | ROS* | biliverdin (H2O2) | reductase | | | |--> NADP+ | | ----- bilirubin * reactive oxygen species, H2O2 in particular Reducing equivalents provided by NADPH The bilirubin reductase cycle, a key antioxidant system in the central nervous system, allows a cell to maintain bilirubin at safe levels, yet still efficient as an antioxidant.

Related

bilirubin biliverdin reductase biliverdin; biliverdine; dihydrobilirubin

General

molecular pathway

References

  1. Sedlak TW, Snyder SH. Messenger molecules and cell death: therapeutic implications. JAMA. 2006 Jan 4;295(1):81-9. PMID: 16391220