bifunctional polynucleotide phosphatase/kinase; polynucleotide kinase-3'-phosphatase; DNA 5'-kinase/3'-phosphatase [includes: polynucleotide 3'-phosphatase, 2'(3')-polynucleotidase, polynucleotide 5'-hydroxyl-kinase] (PNKP)

Function: - catalyzes phosphorylation of DNA at 5'-OH - can also dephosphorylate its 3'-phosphate - plays a role in DNA repair following ionizing radiation or oxidative damage Expression: - highest expression in spleen & testis - lowest expression in small intestine

General

kinase or ATP-phosphotransferase nuclear protein phosphomonoesterase

Properties

SIZE: MW = 57 kD entity length = 521 aa COMPARTMENT: cell nucleus MOTIF: ATP-binding site NAME: ATP-binding site SITE: 372-379

Database Correlations

OMIM 605610 UniProt Q96T60 ENZYME correlations

References

UniProt :accession Q96T60