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bifunctional apoptosis regulator; RING finger protein 47 (BFAR, BAR, RNF47)
Function:
1) apoptosis regulator
2) anti-apoptotic activity
a) apoptosis triggered via death-receptors
b) apoptosis triggered via mitochondrial factors
3) interacts with CASP8, BCL2 & BCL2L1 through SAM domain, HIP1, ESRRBL1 BCAP31
Structure:
- contains 1 RING-type Zn+2 finger
- contains 1 SAM (sterile alpha motif) domain
Compartment:
- integral membrane protein
- endoplasmic reticulum
Expression:
- expressed in brain > small intestine > testes > liver, skeletal muscle
- not expressed in heart, kidney, lung, spleen
General
glycoprotein
phosphoprotein
ring finger protein
transmembrane 4 protein
Properties
SIZE: entity length = 450 aa
MW = 53 kD
COMPARTMENT: endoplasmic reticulum
MOTIF: transmembrane domain {TM1}
transmembrane domain {TM2}
transmembrane domain {TM3}
transmembrane domain {TM4}
cytoplasmic domain {1-140}
MOTIF: RING-finger {34-74}
EFFECTOR-BOUND: Zn+2
FOR-BINDING-OF: DNA motif
cytoplasmic domain {N-TERMINAL}
exoplasmic loop
LOOP#: 1
exoplasmic loop
LOOP#: 2
exoplasmic loop {162-331}
MOTIF: sterile alpha motif
NAME: sterile alpha motif
SITE: 182-249
N-glycosylation site {N232}
transmembrane domain {141-161}
exoplasmic loop {382-404}
cytoplasmic loop {353-360}
cytoplasmic domain {C-TERMINAL}
transmembrane domain {332-352}
transmembrane domain {361-381}
MOTIF: Ser phosphorylation site {S376}
transmembrane domain {405-425}
cytoplasmic domain {426-450}
Database Correlations
UniProt Q9NZS9
Pfam PF00536
Entrez Gene 51283
Kegg hsa:51283
References
UniProt :accession Q9NZS9