bifunctional aminoacyl-tRNA synthetase (prolyl tRNA synthetase, glutamyl tRNA synthetase, EPRS, GLNS, PARS, QARS, QPRS, PIG32)

Function: - component of the multisynthetase complex - interacts with DUS2L ATP + L-glutamate + tRNA(Glu) AMP + diphosphate + L-glutamyl-tRNA(Glu) ATP + L-proline + tRNA(Pro) AMP + diphosphate + L-prolyl-tRNA(Pro) Structure: - WHEP-TRS domain is involved in RNA binding - aminoacyl-tRNA synthetase family - contains 3 WHEP-TRS domains - N-terminal section, amino acyl tRNA synthetase-1 - C-terminal section, amino acyl tRNA synthetase-2 Note: originally thought to be a glutaminyl-tRNA synthetase

General

amino acyl tRNA synthetase multifunctional enzyme phosphoprotein

Properties

SIZE: entity length = 1512 aa MW = 171 kD MOTIF: Glutamyl-tRNA synthetase {164-759} MOTIF: "HIGH" region {204-214} "KMSKS" region {432-436} ATP-binding site NAME: ATP-binding site SITE: 435-435 WHEP-TRS 1 {749-805} 3 X 57 AA approximate repeats {760-956} MOTIF: WHEP-TRS 2 {822-878} Ser phosphorylation site {S885} Ser phosphorylation site {S886} Ser phosphorylation site {S891} Thr phosphorylation site {T898} WHEP-TRS 3 {900-956} Charged {959-991} Ser phosphorylation site {S1000} Prolyl-tRNA synthetase {1007-1512}

Database Correlations

OMIM 138295 UniProt P07814 PFAM correlations ENZYME correlations

References

UniProt :accession P07814