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dystrobrevin beta; DTN-B; beta-dystrobrevin (DTNB)
Function:
- interacts with dystrophin short form DP71 & syntrophins SNTG1 & SNTG2
- binds dystrobrevin binding protein 1
Structure:
- the coiled coil domain may mediate the interaction with dystrophin
- belongs to the dystrophin family, Dystrobrevin subfamily
- contains 1 ZZ-type Zn+2 finger
Compartment:
- cytoplasm
Alternative splicing:
- named isoforms=4
- additional isoforms seem to exist
- at least pne isoform may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay
Expression:
- highly expressed in brain, kidney & pancreas
General
dystrobrevin
zinc finger protein
Properties
SIZE: entity length = 627 aa
MW = 71 kD
COMPARTMENT: cytoplasm
MOTIF: Zn finger ZZ-type
NAME: Zn finger ZZ-type
SITE: 237-284
EFFECTOR-BOUND: Zn+2
binding site
SITE: 399-448
FOR-BINDING-OF: syntrophin
coiled coil {428-529}
Database Correlations
OMIM 602415
UniProt O60941
PFAM correlations
Entrez Gene 1838
Kegg hsa:1838
References
- UniProt :accession O609411) OMIM :accession 602415
- Entrez Gene :accession 1838