Contents

Search

beta-carotene

beta-Carotene is a precursor for vitamin A. Pathology: - excess consumption associated with carotenodermia - beta-carotene may increase the risk for lung cancer (RR=1.20) & stomach cancer (RR=1.54) [4] - beta carotene 20-30 mg/day associated with increased cardiovascular mortality & increased risk of lung cancer in those who smoke or had workplace asbestos exposure [6] Clinical trials: - beta-Carotene supplements have been touted for health benefits; - meta-analysis of 8 randomized trials involving 138,000 subjects followed for as long as 6 years, overall mortality & cardiovascular mortality was higher in the beta-carotene group (7.4% vs 7.0% & 3.4% vs. 3.1%, respectively) - subjects taking beta-carotene 50 mg QOD for a mean of 18 years had modest but significantly lower risk for cognitive decline than placebo group - no baseline cognitive measures obtained, - no benefits were seen after 1 year [3] Notes: - routine supplementation to prevent cardiovascular disease not indicated [5]

Related

alpha-carotene carotene in serum vitamin supplementation

General

carotenoid vitamin A

Properties

Database Correlations

PUBCHEM correlations

References

  1. Journal Watch 24(1):7, 2004
  2. Journal Watch 23(16):125, 2004 Vivekananthan DP et al, Lancet 361:2017, 2003 PMID: 12814711
  3. Grodstein F et al, A randomized trial of beta-carotene supplementation and cognitive function in men: The physicians' health study II. Arch Intern Med 2007, 167:2184 PMID: 17998490 - Yaffe K Antioxidants and prevention of memory decline: Does duration of use matter? Arch Intern Med 2007, 167:2167 PMID: 17998489
  4. Druesne-Pecollo N, Latino-Martel P, Norat T, et al. Beta-carotene supplementation and cancer risk: a systematic review and meta-analysis of randomized controlled trials. Int J Cancer. 2010;127:172-184 PMID: 19876916
  5. Medical Knowledge Self Assessment Program (MKSAP) 19 American College of Physicians, Philadelphia 2022
  6. US Preventive Services Task Force Vitamin, Mineral, and Multivitamin Supplementation to Prevent Cardiovascular Disease and Cancer. US Preventive Services Task Force Recommendation Statement. JAMA. 2022;327(23):2326-2333. June 21 PMID: 35727271

Substructures

isoprene

Component-of

alpha tocopherol/ascorbate/beta carotene/calcium carbonate/cholecalciferol/cobalamin/docosahexaenoate/folic acid/magnesium oxide/nicotinamide/pyridoxine/riboflavin/thiamine/zinc oxide alpha tocopherol/ascorbate/beta carotene/calcium carbonate/cholecalciferol/cobalamin/ferrous fumarate/folic acid/nicotinamide/pantothenate/pyridoxine/riboflavin/sodium docusate/thiamine/zinc oxide alpha tocopherol/ascorbate/beta carotene/calcium carbonate/cholecalciferol/cobalamin/folic acid/magnesium oxide/nicotinamide/pyridoxine/riboflavin/thiamine/zinc oxide alpha tocopheryl acetate/ascorbate/beta carotene/cobalamin/ergocalciferol/folic acid/nicotinic acid/pantothenate/pyridoxine/retinol/riboflavin/thiamine alpha tocopheryl acetate/ascorbate/beta carotene/copper sulfate/zinc oxide alpha tocopheryl acetate/ascorbate/beta carotene/copper/copper sulfate/lutein/sodium selenite/zinc/zinc oxide alpha tocopheryl acetate/ascorbate/beta carotene/copper/copper sulfate/sodium selenite/zinc/zinc oxide alpha tocopheryl acetate/ascorbate/beta carotene/cuprous oxide/zinc oxide alpha tocopheryl acetate/ascorbate/beta carotene/zinc oxide ascorbate/beta carotene/calcium carbonate/carbonyl iron/cholecalciferol/cobalamin/folic acid/magnesium oxide/nicotinamide/pyridoxine/riboflavin/sodium docusate/thiamine/zinc oxide Ocuvite PreserVision; AREDS formulation