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beta-1,4 N-acetylgalactosaminyltransferase 2 (Sd(a) beta-1,4-GalNAc transferase, UDP-GalNAc:Neu5Aca2-3Galb-R b1,4-N-acetylgalactosaminyltransferase, B4GALNT2, GALGT2)

Function: - glycosylation - role in synthesis of the Sd(a) antigen - transfers a beta-1,4-linked GalNAc to the galactose residue of an alpha-2,3-sialylated chain Structure: belongs to the glycosyltransferase 2 family Compartment: Golgi membrane Alternative splicing: named isoforms=2 Expression: - widely expressed - expressed in colon > kidney, stomach, ileum & rectum

General

beta-1,4-N-acetylgalactosaminyltransferase (B4GALNT) glycoprotein membrane protein

Properties

SIZE: MW = 63 kD entity length = 566 aa COMPARTMENT: golgi MOTIF: transmembrane domain {68-88}

Database Correlations

UniProt Q8NHY0 Pfam PF00535

References

  1. UniProt :accession Q8NHY0
  2. GlycoGene database http://ggdb.muse.aist.go.jp/GGDB/index.jsp