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beta-1,4 N-acetylgalactosaminyltransferase 1; N-acetylneuraminyl-galactosylglucosylceramide; GM2/GD2 synthase; GalNAc-T (B4GALNT1, GALGT, SIAT2)
Function:
- role in biosynthesis of gangliosides GM2, GD2 & GA2
- glycosylation
Structure:
- homodimer, disulfide-linked
- belongs to the glycosyltransferase 2 family
Compartment: Golgi membrane
General
beta-1,4-N-acetylgalactosaminyltransferase (B4GALNT)
glycoprotein
membrane protein
Properties
SIZE: MW = 59 kD
entity length = 533 aa
COMPARTMENT: golgi
MOTIF: transmembrane domain {8-25}
N-glycosylation site {N79}
cysteine residue {C80}
MODIFICATION: cysteine residue {C412}
cysteine residue {C82}
MODIFICATION: cysteine residue {C529}
N-glycosylation site {N179}
N-glycosylation site {N274}
cysteine residue {C412}
MODIFICATION: cysteine residue {C80}
cysteine residue {C429}
MODIFICATION: cysteine residue {C476}
cysteine residue {C476}
MODIFICATION: cysteine residue {C429}
cysteine residue {C529}
MODIFICATION: cysteine residue {C82}
Database Correlations
OMIM 601873
UniProt Q00973
Pfam PF00535
References
- UniProt :accession Q00973
- GlycoGene database
http://ggdb.muse.aist.go.jp/GGDB/index.jsp