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alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase; beta-1,2-N-acetylglucosaminyltransferase II; GlcNAc-T II; GNT-II; mannoside acetylglucosaminyltransferase 2; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II (MGAT2)
Function:
- catalyzes an essential step in the conversion of oligo- mannose to complex N-glycans
- protein modification; protein glycosylation
Compartment:
- Golgi membrane
- single-pass type 2 membrane protein
Pathology:
- defects in MGAT2 are the cause of congenital disorder of glycosylation type 2A
General
aminotransferase
glycoprotein
membrane protein
Properties
SIZE: entity length = 447 aa
MW = 52 kD
COMPARTMENT: golgi
MOTIF: transmembrane domain {10-29}
N-glycosylation site {N69}
N-glycosylation site {N86}
Database Correlations
OMIM correlations
MORBIDMAP 602616
UniProt Q10469
Pfam PF05060
Entrez Gene 4247
Kegg hsa:4247
ENZYME 2.4.1.143
References
- UniProt :accession Q10469
- GeneReviews
http://www.ncbi.nlm.nih.gov/sites/genetests/lab/gene/MGAT2
- GGDB; Note: glycogene database
http://riodb.ibase.aist.go.jp/rcmg/ggdb/
- Functional glycomics gateway - GTase
alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyl-
transferase
http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewglycoEnzyme.jsp?gbpId=gt_hum_534