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betatrophin; angiopoietin-like protein 8; hepatocellular carcinoma-associated protein TD26; TD26; RIFL; C19orf80; lipasin; Angptl-8
Function:
- increases pancreatic beta-cell proliferation [1]
- improves glycemic control (article retracted) [2,3]
Compartment: secreted (putative)
Expression:
- liver
- adipose tissue
Notes:
- based on report from mouse model [1]
- article [1] retracted [2,3]
General
secreted protein
Properties
SIZE: entity length = 198 aa
MW = 22 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-21}
Database Correlations
UniProt Q6UXH0
References
- Yi P, Park SJ, Melton DA
Betatrophin: A Hormone that Controls Pancreatic beta Cell
Proliferation.
Cell, 25 April 2013
PMID: 23623304
http://www.cell.com/abstract/S0092-8674(13)00449-2
- Cox AR, Barrandon O, Cai EP et al
Resolving Discrepant Findings on ANGPTL8 in beta-Cell
Proliferation: A Collaborative Approach to Resolving the
Betatrophin Controversy.
PLoS One. 2016 Jul 13;11(7):e0159276.
PMID: 27410263 Free PMC Article
- Yi P, Park JS, Melton DA
Retraction Notice to: Betatrophin: A Hormone that Controls
Pancreatic Beta-Cell Proliferation
Cell. 2016 Dec 27
PMID: 28038792
http://www.cell.com/cell/fulltext/S0092-8674(16)31733-0