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berylliosis

Etiology: 1) acute beryllium exposure by inhalation 2) chronic beryllium exposure Epidemiology: 1) ceramic workers 2) beryllium processors 3) some aerospace workers 4) workers in light bulb or semiconductor factories [2] Pathology: 1) acute berylliosis a) tracheobronchitis b) chemical pneumonitis 2) chronic berylliosis a) delayed-type hypersensitivity reaction b) sarcoid-like granulomatous disease Clinical manifestations: resembles sarcoidosis Laboratory: beryllium lymphocyte transformation test Radiology: 1) resembles sarcoidosis 2) chest X-ray: - predominantly upper lobe interstitial infiltrates Differential diagnosis: sarcoidosis Management: - corticosteroids for symptomatic patients

Related

beryllium [Be] sarcoidosis

General

occupational lung disease granulomatous disease

References

  1. Mayo Internal Medicine Board Review, 1998-99, Prakash UBS (ed) Lippincott-Raven, Philadelphia, 1998, pg 759
  2. Medical Knowledge Self Assessment Program (MKSAP) 14, American College of Physicians, Philadelphia 2006