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benzodiazepine toxicity

also see benzodiazepine Clinical manifestations: - slurred speech - ataxia - altered mental status,or depressed mental status Management: - endotracheal intubation for unresponsive patients with respiratory depression, especially if opiates are in the mix* - flumazenil rarely used because it can precipitate seizures in patients with a tolerance to benzodiazepines [1,2] * respiratory depression effects of benzodiazepines are relatively small in comparison to those of opiates [4]

Related

benzodiazepine

General

toxicity; poisoning; overdose

References

  1. NEJM Knowledge+ Question of the Week. June 5, 2018 https://knowledgeplus.nejm.org/question-of-week/1826/
  2. Seger DL. Flumazenil--treatment or toxin. J Toxicol Clin Toxicol 2004; 42:209 PMID: 15214628
  3. An H, Godwin J. Flumazenil in benzodiazepine overdose. CMAJ. 2016 Dec 6;188(17-18):E537. PMID: 27920113 Free PMC Article
  4. Medical Knowledge Self Assessment Program (MKSAP) 19 American College of Physicians, Philadelphia 2022