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belumosudil (Rezurock)

Indications: - treatment of chronic graft-versus-host disease Contraindications: - can cause fetal harm Dosage: - 200 mg PO QD Tabs: 200 mg Adverse effects: - > 20%: infections, asthenia, nausea, diarrhea, dyspnea, cough, edema, hemorrhage, abdominal pain, musculoskeletal pain, headache, hypophosphatemia, increased serum gamma glutamyl transferase, lymphopenia, hypertension Mechanism of action: - inhibits ROCK1 & ROCK2

Interactions

drug adverse effects of immunosuppressive agents monitor with immunosuppressive agents

General

protein kinase inhibitor immunosuppressive agent

References

  1. HIGHLIGHTS OF PRESCRIBING INFORMATION Rezurock (belumosudil) tablets, for oral use https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/214783s000lbl.pdf
  2. Medscape: belumosudil (Rx) https://reference.medscape.com/drug/rezurock-belumosudil-4000186