belladonna/ergotamine/phenobarbital (Bellergal-S, Spastrin)

Tradenames: Bellergal-S, Spastrin. belladonna alkaloids: 0.2 mg, phenobarbital: 40 mg, ergotamine tartrate 0.6 mg. Indications: 1) menopausal disorders 2) gastrointestinal disorders 3) recurrent throbbing headaches Contraindications: pregnancy category X Dosage: 1 tab PO BID Adverse effects: 1) common (> 10%) - constipation - decreased sweating - dry mouth, nose, throat - irritation at the site of injection - peripheral vascular effects (numbing & tingling of fingers & toes) - drowsiness - dizziness - diarrhea - nausea/vomiting 2) less common (1-10%) - decreased flow of breast milk, difficulty swallowing, increased sensitivity to light, chest pain, transient tachycardia or bradycardia, muscle pains in extremities, leg weakness 3) uncommon (< 1%) - skin rash, confusion, increased intraocular pain, orthostatic hypotension, bloated feeling, difficulty urinating, blurred vision, drowsiness, headache, loss of memory, fatigue, palpitations, ventricular fibrillation, ataxia Overdose: - physostigmine 1-2 mg IV/SC (0.02 mg/kg for children) to reverse effects of belladonna Drug interactions: - CNS depressants

Related

naloxone (Narcan, Evzio, ReVive) physostigmine (Antilirium, Isopto Eserine)

General

antispasmodic pharmacologic combination

References

Kaiser Permanente Northern California Regional Drug Formulary, 1998

Components

belladonna alkaloid ergotamine (Ergostat) phenobarbital; PB; PHB (Luminal, Barbita, Solfoton)