BCoR-like protein 1 (BCL6 corepressor-like protein 1, BCoR-L1, BCORL1)

Function: - transcriptional corepressor - may specifically inhibit gene expression when recruited to promoter regions by sequence specific DNA-binding proteins such as BCL6 - repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor - interacts with CTBP1 - interacts with HDAC4, HDAC5 & HDAC7 - phosphorylated upon DNA damage, probably by ATM or ATR Structure: - belongs to the BCOR family - contains 3 ANK repeats Compartment: nucleus Alternative splicing: named isoforms=3 Expression: - detected in testis & prostate - detected at lower levels in peripheral blood leukocytes & spleen

General

ankyrin repeat domain protein (ANKRD) phosphoprotein transcriptional silencer (transcriptional repressor)

Properties

SIZE: entity length = 1711 aa MW = 183 kD COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S48} proline-rich region SITE: 198-649 MOTIF: proline residue (SEVERAL) nuclear translocation signal {1328-1336} ankyrin repeat NAME: ankyrin repeat SITE: 1455-1484 ankyrin repeat NAME: ankyrin repeat SITE: 1488-1517 ankyrin repeat NAME: ankyrin repeat SITE: 1521-1549

Database Correlations

UniProt Q5H9F3 Pfam PF00023

References

UniProt :accession Q5H9F3