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BCL2/adenovirus E1B 19 kD protein-interacting protein 3-like; NIP3-like protein X; NIP3L; BCL2/adenovirus E1B 19 kD protein-interacting protein 3A; adenovirus E1B19K-binding protein B5 (BNIP3L, BNIP3A, BNIP3H, NIX)
Function:
- induces apoptosis
- interacts with viral & cellular anti-apoptosis proteins
- can overcome the suppressors BCL-2 & BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis
- may function as a tumor suppressor
- inhibits apoptosis induced by BNIP3
- undergoes progressive proteolysis to an 11 kD C-terminal fragment, which is blocked by the proteasome inhibitor lactacystin
- self-associates
- interacts with BNIP3 & STEAP3
- interacts with human adenovirus-2 E1B 19 kD protein
Structure: belongs to the NIP3 family
Compartment:
- nucleus envelope
- endoplasmic reticulum
- mitochondrion
- single-pass membrane protein (putative)
General
membrane protein
mitochondrial protein
nuclear protein
phosphoprotein
Properties
SIZE: entity length = 219 aa
MW = 24 kD
COMPARTMENT: mitochondria
cell nucleus
endoplasmic reticulum
MOTIF: Ser phosphorylation site {S62}
Ser phosphorylation site {S63}
Ser phosphorylation site {S117}
Ser phosphorylation site {S118}
Ser phosphorylation site {S120}
transmembrane domain {188-208}
Database Correlations
OMIM 605368
UniProt O60238
Pfam PF06553
Entrez Gene 665
KEGG correlations
References
UniProt :accession O60238