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bax subfamily protein
Function:
- Bax subfamily proteins promote apoptosis.
- monomers are thought to be inactive
- homo-oligomers are thought to promote apoptosis.
- oligomerization & insertion into the outer mitochondrial membrane may release cytochrome c from mitochondria.
Specific
Bcl-2 associated protein X (BAX)
Bcl-2 homologous antagonist/killer 2; apoptosis regulator BAK-2 (BCL2L7P1 BAK2)
Bcl-2 homologous antagonist/killer; apoptosis regulator BAK; Bcl-2-like protein 7; Bcl2-L-7 (BAK1, BAK, BCL2L7, CDN1)
Bcl-2-related ovarian killer protein; Bcl-2-like protein 9; Bcl2-L-9; Hbok (BOK, BCL2L9)
General
bcl-2 family protein
oligomerizing protein
Properties
MOTIF: BH3 domain
NAME: BH3 domain
BH1 domain
NAME: BH1 domain
BH2 domain
NAME: BH2 domain
transmembrane domain {C-TERMINAL}
References
- Cheng EH, Wei MC, Weiler S, Flavell RA, Mak TW, Lindsten T,
Korsmeyer SJ.
BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing
BAX- and BAK-mediated mitochondrial apoptosis.
Mol Cell. 2001 Sep;8(3):705-11.
PMID: 11583631
- Adams JM, Cory S.
Life-or-death decisions by the Bcl-2 protein family.
Trends Biochem Sci. 2001 Jan;26(1):61-6. Review.
PMID: 11165519