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zinc finger protein basonuclin-1 (BNC1, BNC)
Function:
- likely to be a transcription factor specific for squamous epithelium & for the constituent keratinocyte at a stage either prior to or at the very beginning of terminal differentiation
- may play a role in the differentiation of spermatozoa & oocytes
- phosphorylation on Ser-537 & Ser-541 leads to cytoplasmic localization
Structure: contains 6 C2H2-type Zn+2 fingers
Compartment:
- nucleus (putative). cytoplasm
- elocates to the midpiece of the flagellum during late spermiogenesis in spermatids (putative)
Expression:
- expressed in epidermis, testis & foreskin, & to a lower extent in thymus, spleen, mammary glands, placenta, brain & heart
General
C2H2 type zinc finger protein
DNA-binding protein
phosphoprotein
Properties
SIZE: entity length = 994 aa
MW = 111 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: Hydrophobic {240-249}
Zn finger C2H2-type
SITE: 357-380
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 385-414
EFFECTOR-BOUND: Zn+2
nuclear translocation signal {533-539}
MOTIF: Ser phosphorylation site {S537}
Ser phosphorylation site {S541}
Zn finger C2H2-type
SITE: 720-743
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 748-775
EFFECTOR-BOUND: Zn+2
serine-rich region {859-876}
MOTIF: serine residue (SEVERAL)
Zn finger C2H2-type
SITE: 928-951
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 956-983
EFFECTOR-BOUND: Zn+2
Database Correlations
OMIM 601930
UniProt Q01954
Pfam PF00096
Entrez Gene 646
Kegg hsa:646
References
UniProt :accession Q01954