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calponin-1; calponin H1, smooth muscle; basic calponin (CNN1)
Function:
- thin filament-associated protein that is implicated in regulation & modulation of smooth muscle contraction
- capable of binding to actin, calmodulin, troponin C & tropomyosin
- interaction of calponin with actin inhibits actomyosin Mg-ATPase activity (putative)
- part of cGMP kinase signaling complex
Structure:
- belongs to the calponin family
- contains 3 calponin-like repeats
- contains 1 CH (calponin-homology) domain
Expression:
- smooth muscle, & tissues containing significant amounts of smooth muscle
General
calponin
Properties
SIZE: entity length = 297 aa
MW = 33 kD
COMPARTMENT: cytoplasm
MOTIF: calponin homology domain
NAME: calponin homology domain
SITE: 28-131
Ca+2-binding site
Calponin-like {164-189}
Calponin-like {204-229}
Calponin-like {243-268}
Database Correlations
OMIM 600806
UniProt P51911
PFAM correlations
Entrez Gene 1264
Kegg hsa:1264
References
UniProt :accession P51911