base excision repair (BER) complex

Function: - base excision repair Structure: - subunits include: XRCC1, PARP1, PARP2, POLB & LRIG3

Properties

SUBUNITS: Xrcc1 poly [ADP-ribose] polymerase 1 COMPARTMENT: cell nucleus MOTIF: DNA-binding motif SITE: 2-372 acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl Zn finger PARP-type NAME: Zn finger PARP-type SITE: 9-93 EFFECTOR-BOUND: Zn+2 MOTIF: Ser phosphorylation site {S41} Zn finger PARP-type NAME: Zn finger PARP-type SITE: 113-203 EFFECTOR-BOUND: Zn+2 MOTIF: Ser phosphorylation site {S179} nuclear translocation signal {207-209} nuclear translocation signal {221-226} Thr phosphorylation site {T368} Automodification {373-524} MOTIF: BRCA1 C-terminal (BRCT) motif SITE: 385-476 PARP alpha-helical {662-779} Ser phosphorylation site {S782} catalytic domain SITE: 788-1014 poly [ADP-ribose] polymerase 2 COMPARTMENT: cell nucleus MOTIF: DNA-binding motif SITE: 1-88 MOTIF: nuclear translocation signal {4-7} nuclear translocation signal {35-40} PARP alpha-helical {231-348} catalytic domain SITE: 356-583 DNA polymerase beta COMPARTMENT: cell nucleus MOTIF: active site leucine-rich repeats and immunoglobulin-like domains protein 3 MOTIF: signal sequence {1-24} leucine-rich repeat SITE: 54-72 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 73-96 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 97-121 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N122} leucine-rich repeat SITE: 123-143 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 144-166 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N156} leucine-rich repeat SITE: 168-189 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 191-214 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 216-237 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 238-261 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 262-285 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N274} leucine-rich repeat SITE: 287-309 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 311-333 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 334-357 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 359-384 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 385-408 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 410-432 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 434-461 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N442} N-glycosylation site {N469} immunoglobulin superfamily domain {499-598} MOTIF: N-glycosylation site {N515} cysteine residue {C520} MODIFICATION: cysteine residue {C581} cysteine residue {C581} MODIFICATION: cysteine residue {C520} immunoglobulin superfamily domain {603-692} MOTIF: cysteine residue {C624} MODIFICATION: cysteine residue {C676} cysteine residue {C676} MODIFICATION: cysteine residue {C624} N-glycosylation site {N688} immunoglobulin superfamily domain {697-783} MOTIF: cysteine residue {C718} MODIFICATION: cysteine residue {C767} N-glycosylation site {N729} cysteine residue {C767} MODIFICATION: cysteine residue {C718} transmembrane domain {810-830} N-glycosylation site {N905} N-glycosylation site {N987} N-glycosylation site {N999} N-glycosylation site {N1016}

References

UniProt :accession P09874

Components

DNA polymerase beta (POLB, DNA polymerase X) leucine-rich repeats and immunoglobulin-like domains protein 3 (LIG-3, LRIG3, LIG3, UNQ287/PRO326/PRO335) poly [ADP-ribose] polymerase 1; PARP-1; NAD(+) ADP-ribosyltransferase 1; ADPRT 1; poly[ADP-ribose] synthase 1 (PARP1, ADPRT, PPOL) poly [ADP-ribose] polymerase 2; PARP-2; hPARP-2; NAD(+) ADP-ribosyltransferase 2; ADPRT-2; poly[ADP-ribose] synthase 2; pADPRT-2 (PARP2 ADPRT2 ADPRTL2)