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band 4.1-like protein 3; 4.1B; differentially expressed in adenocarcinoma of the lung protein 1; DAL-1 (EPB41L3, DAL1, KIAA0987)
Function:
- interacts with CADM1
Structure: contains 1 FERM domain
Compartment: cytoplasm, cytoskeleton (putative)
Alternative splicing:
- named isoforms=3; A, B, C
- comment=additional isoforms seem to exist
Expression:
- expressed at high levels in brain
- lower expression in kidney, intestine, & testis
Pathology:
- critical growth regulator in the pathogenesis of meningiomas
Related
adenocarcinoma of the lung
meningioma
protein 4.1; Band 4.1; P4.1; EPB4.1; 4.1R (EPB41 E41P)
General
band 4.1-like protein (EPB41L)
phosphoprotein
Properties
SIZE: entity length = 1087 aa
MW = 121 kD
COMPARTMENT: cytoplasm
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Thr phosphorylation site {T3}
Ser phosphorylation site {S5}
Ser phosphorylation site {S7}
Ser phosphorylation site {S9}
Ser phosphorylation site {S11}
Ser phosphorylation site {S88}
FERM domain
NAME: FERM domain
SITE: 110-391
Hydrophilic {394-513}
MOTIF: Ser phosphorylation site {S420}
Ser phosphorylation site {S443}
Ser phosphorylation site {S460}
Thr phosphorylation site {T462}
Thr phosphorylation site {T469}
actin-binding site
SITE: 514-860
FOR-BINDING-OF: F-actin
MOTIF: Thr phosphorylation site {T703}
Thr phosphorylation site {T704}
Ser phosphorylation site {S708}
Ser phosphorylation site {S760}
Ser phosphorylation site {S762}
Thr phosphorylation site {T784}
Ser phosphorylation site {S787}
Ser phosphorylation site {S788}
C-terminal (CTD) {861-1083}
MOTIF: Ser phosphorylation site {S962}
Thr phosphorylation site {T1081}
Database Correlations
OMIM 605331
UniProt Q9Y2J2
PFAM correlations
Entrez Gene 23136
Kegg hsa:23136
References
- UniProt :accession Q9Y2J2
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org//genes/EPB41L3ID40458ch18p11.html