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band 4.1-like protein 2; generally expressed protein 4.1; 4.1G (EPB41L2)
Function:
- phosphorylated upon DNA damage, probably by ATM or ATR
- interacts with FCGR1A
- interacts with TRPC4
- the CTD domain interacts with FKBP2 (putative)
Structure:
- contains 1 FERM domain
- contains C-terminal CTD domain
Compartment: cytoplasm, cytoskeleton (putative) cell membrane
Alternative splicing: named isoforms=2
Expression: widely expressed
Related
protein 4.1; Band 4.1; P4.1; EPB4.1; 4.1R (EPB41 E41P)
General
band 4.1-like protein (EPB41L)
phosphoprotein
Properties
SIZE: entity length = 1005 aa
MW = 113 kD
COMPARTMENT: cytoplasm
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Ser phosphorylation site {S39}
Ser phosphorylation site {S47}
Ser phosphorylation site {S55}
Ser phosphorylation site {S57}
Ser phosphorylation site {S58}
Ser phosphorylation site {S87}
Tyr phosphorylation site {Y88}
Thr phosphorylation site {T89}
FERM domain
NAME: FERM domain
SITE: 218-499
MOTIF: Ser phosphorylation site {S386}
Ser phosphorylation site {S499}
Hydrophilic {502-610}
MOTIF: Ser phosphorylation site {S550}
Ser phosphorylation site {S598}
actin-binding site
SITE: 611-676
FOR-BINDING-OF: F-actin
MOTIF: Ser phosphorylation site {S614}
Tyr phosphorylation site {Y623}
Ser phosphorylation site {S627}
Ser phosphorylation site {S647}
Ser phosphorylation site {S715}
Ser phosphorylation site {S718}
Thr phosphorylation site {T763}
Tyr phosphorylation site {Y773}
CTD {855-1005}
Database Correlations
OMIM 603237
UniProt O43491
PFAM correlations
Entrez Gene 2037
Kegg hsa:2037
References
UniProt :accession O43491