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Leukocyte-specific transcript 1 protein; protein B144 (LST1 B144)
Function:
- possible role in modulating immune responses
- isoforms 1 & 2 have an inhibitory effect on lymphocyte proliferation
- induces morphological changes including production of filopodia & microspikes when overexpressed in a variety of cell types
- may be involved in dendritic cell maturation
Structure: belongs to the LST1 family
Compartment:
- membrane, Golgi membrane
- intracytoplasmic membrane
- detected in a perinuclear region corresponding to the localization of the Golgi apparatus & throughout the cytoplasm
Alternative splicing: named isoforms=9; additional isoforms seem to exist
Expression:
- expressed in B-cells & macrophages
- expressed in lung, tonsil, thymus, placenta, kidney, fetal spleen, fetal liver & brain
- expression induced by interferon gamma
General
membrane protein
nuclear protein
Properties
SIZE: entity length = 97 aa
MW = 11 kD
COMPARTMENT: cytoplasm
cell nucleus
golgi
MOTIF: transmembrane domain {8-28}
Tyr phosphorylation site {Y88}
Database Correlations
OMIM 109170
UniProt O00453
Pfam PF05083
Entrez Gene 7940
Kegg hsa:7940
References
- UniProt :accession O00453
- OMIM :accession 109170