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Myb-related protein A (A-Myb, MYBL1, AMYB, p90A-myb)
Function:
- strong transcriptional activator
- DNA-binding protein that specifically recognize sequence 5'-YAAC[GT]G-3'
- role in the proliferation &/or differentiation of neurogenic, spermatogenic & B-lymphoid cells
- component of the DREAM complex
- p90A-myb can activate transcription from genes containing myb enhancer element [2]
- A-myb may play a role in spermatogenesis
Structure: contains 3 HTH myb-type DNA-binding domains
Compartment: nucleus
Expression:
- expressed mainly in the testis, B-cells & mitotically active cells in the developing nervous system
Pathology:
- expressed in a variety of lymphoid & solid tumor lines cultured in vitro
Note: short 1/2 life.
Related
A-myb proto-oncogene
General
myb proto-oncogene protein
Properties
SIZE: entity length = 752 aa
MW = 86 kD
COMPARTMENT: cell nucleus
MOTIF: HTH myb-type 1 {30-81}
MOTIF: DNA-binding motif
SITE: 58-81
HTH myb-type 2 {82-137}
MOTIF: DNA-binding motif
SITE: 110-133
HTH myb-type 3 {138-188}
MOTIF: DNA-binding motif
SITE: 161-184
Transcriptional activation domain {230-295}
Negative regulatory domain {298-553}
Database Correlations
OMIM 159405
UniProt P10243
PFAM correlations
Entrez Gene 4603
Kegg hsa:4603
References
- Trauth K et al
Mouse A-myb encodes a trans-activator and is expressed in
mitotically active cells of the developing central nervous
system, adult testis and B lymphocytes
EMBO J 13:5994 1994
PMID: 7813437
- Takahashi T et al,
Human A-myb gene encodes a transcriptional activator containing
the negative regulatory domains.
FEBS Lett 358:89 1995
PMID: 7821437
- Entrez Gene :accession 4603
- UniProt :accession P10243
Component-of
DREAM complex (LINC complex)