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A-kinase anchor protein 8; AKAP-8; A-kinase anchor protein 95 kD; AKAP 95 (AKAP8, AKAP95)
Function:
- anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II)
- binds to dimeric RII-alpha regulatory subunit of PKA during mitosis
- interacts (via C-terminus) with FIGN
Structure: belongs to the AKAP95 family
Compartment:
- nucleus matrix
- associated with the nuclear matrix
- redistributed & detached from condensed chromatin during mitosis
Expression:
- highly expressed in heart, liver, skeletal muscle, kidney & pancreas
Related
protein kinase A
General
A-kinase anchor protein
nuclear protein
phosphoprotein
zinc finger protein
Properties
SIZE: entity length = 692 aa
MW = 76 kD
COMPARTMENT: cell nucleus
MOTIF: glycine-rich region {107-118}
MOTIF: Ser phosphorylation site {S112}
Ser phosphorylation site {S323}
Ser phosphorylation site {S328}
Ser phosphorylation site {S339}
nuclear translocation signal {368-377}
Zinc finger
NAME: Zinc finger
SITE: 390-414
EFFECTOR-BOUND: Zn+2
Zinc finger
NAME: Zinc finger
SITE: 479-504
EFFECTOR-BOUND: Zn+2
binding site
SITE: 572-589
FOR-BINDING-OF: RII
Database Correlations
OMIM 604692
UniProt O43823
Pfam PF04988
Entrez Gene 10270
Kegg hsa:10270
References
UniProt :accession O43823