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A-kinase anchor protein 11; AKAP-11; A-kinase anchor protein 220 kD; AKAP 220; hAKAP220; protein kinase A-anchoring protein 11; PRKA11 (AKAP11, AKAP220, KIAA0629)
Function:
- binds to protein kinase A type II regulatory subunits & anchors/targets them
Structure:
- PKA-RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer
- belongs to the AKAP110 family
Compartment:
- cytoplasm, cytoskeleton, centrosome
- cytoplasmic in premeiotic pachytene spermatocytes & in the centrosome of developing postmeiotic germ cells, while a midpiece/centrosome localization was found in elongating spermatocytes & mature sperm
Expression:
- expressed in heart, brain, lung, liver, kidney, testis & ovary
- weakly expressed in skeletal muscle, pancreas & spleen
Related
protein kinase A
General
A-kinase anchor protein
cytoskeletal protein
phosphoprotein
Properties
SIZE: entity length = 1901 aa
MW = 211 kD
COMPARTMENT: cytoplasm
MOTIF: Ser phosphorylation site {S18}
serine-rich region {238-315}
MOTIF: serine residue (SEVERAL)
Ser phosphorylation site {S422}
Ser phosphorylation site {S433}
Ser phosphorylation site {S448}
Thr phosphorylation site {T1100}
Thr phosphorylation site {T1104}
Ser phosphorylation site {S1169}
Ser phosphorylation site {S1240}
Ser phosphorylation site {S1242}
Ser phosphorylation site {S1337}
Ser phosphorylation site {S1340}
PKA-RII subunit binding {1650-1663}
serine-rich region {1705-1767}
MOTIF: serine residue (SEVERAL)
Database Correlations
OMIM 604696
UniProt Q9UKA4
Entrez Gene 11215
Kegg hsa:11215
References
UniProt :accession Q9UKA4